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Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential

Marie A Bogoyevitch1, Ingrid Boehm, Aaron Oakley

  • 1Cell Signalling Laboratory, Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, University of Western Australia, Crawley, WA 6009, Australia. marieb@cyllene.uwa.edu.au

Biochimica Et Biophysica Acta
|March 17, 2004
PubMed
Summary

The c-Jun N-terminal protein kinases (JNKs) are crucial in cellular stress responses. Inhibiting JNKs shows promise for treating neurodegenerative diseases, obesity, diabetes, and arthritis.

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