Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Identifying multiple tumor-specific epitopes from large-scale screening for overexpressed mRNA.

Søren Buus1, Mogens Helweg Claesson

  • 1Institute of Medical Microbiology and Immunology, and Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. sb@immi.ku.dk

Current Opinion in Immunology
|March 17, 2004
PubMed
Summary

Harnessing CD8(+) cytotoxic T cells (CTLs) for cancer treatment relies on understanding T-cell epitopes. Advances in genomic and proteomic technologies enhance tumor immunotherapy strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measles-mumps-rubella-vaccination at 6 months of age induces measles-specific T cell responses: a randomized controlled trial.

Frontiers in immunology·2025
Same author

Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8<sup>+</sup> T cell responses.

Science advances·2024
Same author

Immunogenicity and reactogenicity following MMR vaccination in 5-7-month-old infants: a double-blind placebo-controlled randomized clinical trial in 6540 Danish infants.

EClinicalMedicine·2024
Same author

Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to <i>Coxiella burnetii</i> vaccination and infection.

Frontiers in immunology·2023
Same author

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses.

bioRxiv : the preprint server for biology·2023
Same author

The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus.

Frontiers in immunology·2023

Area of Science:

  • Immunology
  • Oncology
  • Bioinformatics

Background:

  • Cancer immunotherapy aims to leverage the immune system to eliminate malignant cells.
  • CD8(+) cytotoxic T lymphocytes (CTLs) are key mediators of anti-tumor immunity, recognizing specific tumor antigens.
  • Effective cancer treatment requires a deep understanding of CTL specificity and activation pathways.

Purpose of the Study:

  • To explore the rationale behind T-cell epitope-based cancer treatment strategies.
  • To highlight the importance of identifying tumor-specific CTL epitopes and monitoring CTL responses.
  • To discuss how recent technological advancements can improve tumor immunotherapy.

Main Methods:

  • Leveraging genomic, transcriptomic, and proteomic data to identify T-cell epitopes.

Related Experiment Videos

  • Developing technologies to monitor T-cell responses against tumor antigens.
  • Analyzing CTL specificity and activation mechanisms.

    • Main Results:

    • Recent technological advances provide new opportunities for T-cell epitope discovery.
    • These advances enable the development of more effective tumor immunotherapy approaches.
    • The potential for individualized cancer therapy based on T-cell epitopes is increased.

    Conclusions:

    • T-cell epitope-based strategies hold significant promise for cancer treatment.
    • Exploiting genomic and proteomic data is crucial for advancing tumor immunotherapy.
    • Future approaches can enhance efficacy and enable personalized cancer therapies.