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Updated: Aug 25, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Development and function of CD25+CD4+ regulatory T cells
Zoltán Fehérvari1, Shimon Sakaguchi
1Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogo-in 53, Sakyo-ku, Kyoto 606-8507, Japan.
Abstract:
The essential role played by CD25(+)CD4(+) regulatory T cells (T(R) cells) in the control of physiological as well as pathological immunity is now well established, but many aspects of their biology still remain unclear. One of the unresolved issues regards their development: where does this occur, what signals are required, and how do T(R) cells fit into the larger taxonomy of the T-cell family? Recent data has begun to shed light on the development and function of these important cells.
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