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Updated: Jul 24, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography

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Published on: June 7, 2013

Novel mechanisms responsible for postmenopausal hypertension.

Jane F Reckelhoff¹, Lourdes A Fortepiani

¹Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA. jreckelhoff@physiology.umsmed.edu

Hypertension (Dallas, Tex. : 1979)

|March 17, 2004

Summary

Postmenopausal hypertension is common, but its causes are unclear. The aging female spontaneously hypertensive rat offers a model to study mechanisms like hormonal changes and the renin-angiotensin system (RAS).

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Area of Science:

Cardiovascular Physiology
Endocrinology
Hypertension Research

Background:

Postmenopausal women frequently experience elevated blood pressure, a significant risk factor for cardiovascular disease.
The precise mechanisms driving this postmenopausal hypertension remain incompletely understood.
Potential contributing factors include hormonal shifts, increased endothelin and oxidative stress, renin-angiotensin system (RAS) activation, obesity, type II diabetes, and sympathetic nervous system activity.

Purpose of the Study:

To review potential mechanisms underlying postmenopausal hypertension.
To discuss the utility of the aging female spontaneously hypertensive rat (SHR) as a model for studying these mechanisms.

Main Methods:

Review of existing literature on postmenopausal hypertension.
Characterization of the aging female SHR as a relevant animal model.

Main Results:

Several humoral systems and physiological changes are implicated in postmenopausal hypertension.
The aging female SHR displays characteristics mirroring human postmenopausal hypertension, suggesting its suitability as a research model.

Conclusions:

Further research is needed to fully elucidate the mechanisms of postmenopausal hypertension.
The aging female SHR provides a valuable platform for investigating therapeutic strategies and understanding the pathophysiology of this condition.