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Related Experiment Videos

Gnathostomiasis: clinicopathologic study.

Mario Magaña1, Maud Messina, Fausto Bustamante

  • 1*Hospital General de México/Universidad Nacional Autónoma de México, México City, México. dermatopatologia@att.net.mx

The American Journal of Dermatopathology
|March 17, 2004
PubMed
Summary

Gnathostomiasis, a parasitic infection from raw fish, commonly affects the skin. Histopathology reveals characteristic changes like edema and inflammation, aiding diagnosis even without visible larvae.

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Area of Science:

  • Parasitology
  • Dermatology
  • Pathology

Background:

  • Gnathostomiasis is a systemic parasitic disease transmitted through consuming raw fish.
  • Skin involvement is frequent, manifesting as various eruptions like superficial creeping eruption, pseudofurunculosis, and nodular migratory panniculitis.

Purpose of the Study:

  • To retrospectively analyze clinical and histopathological findings in skin biopsies from gnathostomiasis patients.
  • To identify characteristic histopathological features that aid in diagnosing gnathostomiasis, especially when larvae are not directly observed.

Main Methods:

  • Retrospective analysis of 946 gnathostomiasis cases, with a focus on 66 cases with skin biopsies.
  • Diagnosis based on clinical, epidemiological data, and therapeutic response, supplemented by histopathological examination of biopsies.

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Main Results:

  • Nodular migratory panniculitis of the trunk was the most common skin manifestation.
  • Histopathology confirmed the larva in 15 cases and worm retrieval in 12 cases; characteristic changes like edema, mixed inflammatory infiltrates (eosinophils, lymphocytes, neutrophils), eosinophilic vasculitis, flame figures, necrosis, and hemorrhage were observed in other cases.
  • The majority of affected patients were males aged 20-40 years.

Conclusions:

  • Characteristic histopathological findings in skin biopsies are crucial for diagnosing gnathostomiasis, particularly when the parasite is not readily identified.
  • The study highlights the importance of integrating clinical, epidemiological, and histopathological data for accurate diagnosis and management of cutaneous gnathostomiasis.