Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Systemic mastocytosis. Classification, symptoms, therapy].

Doris M Kraemer1, Susanne M Grunewald, Annette Kolb-Mäurer

  • 1Medizinische Poliklinik der Universität Würzburg, Würzburg. kraemer_d@klinik.uniwuerzburg.de

Medizinische Klinik (Munich, Germany : 1983)
|March 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MMW Fortschritte der Medizin·2026
Same author

'Trichophyton indotineae' is an inaccurate and pejorative term.

Indian journal of dermatology, venereology and leprology·2025
Same author

S1-Leitlinie Onychomykose.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2023
Same author

S1 Guideline onychomycosis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2023
Same author

Diagnostik und Therapie von Mycobacterium-marinum-Infektionen: Ergebnisse einer retrospektiven monozentrischen Studie.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2022
Same author

Diagnosis and therapy of Mycobacterium marinum: a single-center 21-year retrospective analysis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2022
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2016
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2016
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2014
See all related articles

Systemic mastocytoses involve abnormal mast cell growth in tissues. Current therapies manage symptoms as there is no known cure for this clonal disorder.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Systemic mastocytoses are clonal disorders characterized by abnormal mast cell proliferation and infiltration of various organs.
  • These conditions can arise from mutations in the c-kit protooncogene, which encodes the stem cell receptor (CD117).

Observation:

  • The World Health Organization (WHO) classification (2000) categorizes mastocytoses into cutaneous and systemic types.
  • Systemic mastocytosis is further divided into indolent forms with good prognosis and aggressive subtypes with poor prognosis, including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with associated clonal hematologic non-mast-cell disease.

Findings:

  • Therapeutic strategies for systemic mastocytosis are symptom-dependent and do not offer a cure.
  • Management includes dietary modifications, avoidance of skin irritants, H1/H2 blockers, steroids, leukotriene receptor antagonists, and PUVA therapy.

Related Experiment Videos

  • Emergency treatment with epinephrine is recommended for systemic reactions like hypotension or syncope.

    • Implications:

    • Understanding the classification and genetic basis of systemic mastocytoses is crucial for accurate diagnosis and prognosis.
    • Tailored, multidisciplinary symptom management is essential for improving the quality of life for patients with systemic mastocytosis.