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Related Experiment Video

Updated: Jul 17, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

Prolonged vitamin C supplementation and recovery from eccentric exercise.

D Thompson¹, D M Bailey, J Hill

¹Department of Sport and Exercise Science, University of Bath, Bath, BA2 7AY, UK. d.thompson@bath.ac.uk

European Journal of Applied Physiology

|March 17, 2004

Summary

Vitamin C supplementation did not impact muscle damage markers or interleukin-6 levels after low-metabolic-cost exercise. This suggests vitamin C does not influence recovery from eccentric exercise with minimal metabolic demand.

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Area of Science:

Exercise Physiology
Nutritional Biochemistry

Background:

Previous research indicated vitamin C supplementation influences recovery from demanding exercise, notably affecting plasma interleukin-6 (IL-6).
The role of IL-6 in metabolism raises questions about whether vitamin C's effect is on muscle damage response or metabolic demand interaction.

Purpose of the Study:

To investigate vitamin C's effect on exercise-induced muscle damage and IL-6 response during exercise with low metabolic cost.
To differentiate between vitamin C's impact on muscle damage versus metabolic response.

Main Methods:

Fourteen male subjects were divided into vitamin C (200 mg twice daily) and placebo groups.
Subjects underwent 30 minutes of downhill running (-18% gradient) to induce muscle damage.
Muscle damage markers (creatine kinase, myoglobin), muscle soreness, and plasma IL-6 were monitored for 3 days post-exercise.

Main Results:

Vitamin C supplementation increased plasma vitamin C concentrations but did not alter muscle damage markers or soreness compared to placebo.
Downhill running elevated plasma IL-6 in both groups, with no significant difference between vitamin C and placebo.
Circulating markers of muscle damage and soreness were similar between groups.

Conclusions:

Vitamin C supplementation does not appear to affect muscle damage, soreness, or interleukin-6 concentrations following eccentric exercise with a low metabolic component.
These findings suggest vitamin C's role in exercise recovery may be context-dependent, specifically related to the metabolic demands of the activity.