Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephron function and perinatal homeostasis.

M Horster

    Annales De Recherches Veterinaires. Annals of Veterinary Research
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals how the developing kidney (nephron) regulates body fluid balance and concentration during early life. Key changes in kidney structure and transport functions ensure proper volume and osmotic control in newborns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Embryonic epithelial membrane transporters.

    American journal of physiology. Renal physiology·2000
    Same author

    Chloride channels ClC-2 and ICln mRNA expression differs in renal epithelial ontogeny.

    Kidney international. Supplement·1998
    Same author

    Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes.

    Kidney international. Supplement·1998
    Same author

    Single cell RT-PCR analysis of ClC-2 mRNA expression in ureteric bud tip.

    The American journal of physiology·1998
    Same author

    CFTR mRNA and its truncated splice variant (TRN-CFTR) are differentially expressed during collecting duct ontogeny.

    FEBS letters·1998
    Same author

    Analysis of mouse glomerular podocyte mRNA by single-cell reverse transcription-polymerase chain reaction.

    Kidney international·1998
    Same journal

    [Lentivirus expression at the moment of lambing modifies the leukocyte number in the milk of multiparous ewes].

    Annales de recherches veterinaires. Annals of veterinary research·1992
    Same journal

    Conjunctival vaccination of pregnant ewes and goats with Brucella melitensis Rev 1 vaccine: safety and serological responses.

    Annales de recherches veterinaires. Annals of veterinary research·1992
    Same journal

    [Actinomyces pyogenes: conventional and Api system bacteriologic study of 103 strains isolated from ruminants].

    Annales de recherches veterinaires. Annals of veterinary research·1992
    Same journal

    Influence of the stage of pregnancy on gentamicin disposition in the ewe.

    Annales de recherches veterinaires. Annals of veterinary research·1992
    Same journal

    Effect of vitamin E supplementation and of health status of mammary gland on immunoglobulin concentration in milk of dairy cows.

    Annales de recherches veterinaires. Annals of veterinary research·1992
    Same journal

    [Content of nitrate in milk. Relationship with its concentration in the water supply for livestock].

    Annales de recherches veterinaires. Annals of veterinary research·1992
    See all related articles

    Area of Science:

    • Nephrology
    • Developmental Biology
    • Physiology

    Background:

    • Perinatal kidney development involves complex adaptations in both proximal and distal nephron segments.
    • Understanding these changes is crucial for comprehending fluid and electrolyte homeostasis in newborns.

    Purpose of the Study:

    • To elucidate the functional and structural maturation of the proximal and distal nephron during the perinatal period.
    • To detail the regulation of extracellular volume and osmotic activity by the developing kidney.

    Main Methods:

    • Analysis of glomerular capillary permeability coefficient (Kf) and hydraulic conductance (Lp).
    • Assessment of proximal tubule hydrostatic hydraulic conductance and response to protein gradients.
    • Evaluation of paracellular pathways, basolateral membrane area, and Na-K-ATPase activity.

    Related Experiment Videos

  • Investigation of inner medullary urea content, fluid dilution in the loop of Henle, and thick ascending segment transport.
  • Examination of ultrastructural changes and Na-K-ATPase activity in the diluting segment (TAL).
  • Characterization of the centrifugal pattern of renal maturation.

    • Main Results:

    • Glomerular Kf changes are linked to increased Lp; proximal tubule conductance is high during perinatal adaptation.
    • Paracellular pathways are vital for proximal tubule absorption during differentiation.
    • Basolateral membrane area and Na-K-ATPase activity increase, maintaining enzyme site numbers during ontogeny.
    • The loop of Henle progressively dilutes luminal fluid; the thick ascending segment enhances Na-Chloride transport.
    • Renal maturation follows a centrifugal pattern, creating intracortical functional gradients.

    Conclusions:

    • The proximal nephron adapts its structure and function to regulate extracellular volume through changes in hydraulic conductance and transport pathways.
    • The distal nephron matures to control osmotic activity by modifying urea content and transport in the loop of Henle and thick ascending segment.
    • These coordinated developmental processes ensure proper fluid and electrolyte balance during the critical perinatal period.