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Choroid plexus tumors in children.

Nalin Gupta1

  • 1Division of Pediatric Neurosurgery, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M-779, San Francisco, CA 94143, USA. guptan@neurosurg.ucsf.edu

Neurosurgery Clinics of North America
|March 18, 2004
PubMed
Summary

Choroid plexus tumors are brain tumors primarily affecting young children. While surgical removal often cures papilloma, carcinoma treatment remains challenging with poor long-term survival rates.

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Area of Science:

  • Neuro-oncology
  • Pediatric Neurosurgery
  • Tumor Biology

Background:

  • Choroid plexus tumors are a distinct group of central nervous system neoplasms.
  • These tumors predominantly affect the pediatric population.
  • Understanding their biology and treatment is crucial for improving outcomes.

Purpose of the Study:

  • To review the characteristics and management of choroid plexus tumors.
  • To highlight the differences in prognosis between papilloma and carcinoma subtypes.
  • To emphasize the need for optimized treatment strategies.

Main Methods:

  • Review of existing literature on choroid plexus tumors.
  • Analysis of surgical outcomes and adjunctive therapies.
  • Discussion of prognostic factors and survival data.

Main Results:

  • Choroid plexus papilloma (CPP) is generally curable with surgical resection.
  • Carcinoma of the choroid plexus (CPC) requires multimodal treatment including surgery, chemotherapy, and radiation.
  • Long-term survival for CPC remains significantly poor despite aggressive treatment.

Conclusions:

  • Surgical resection is the cornerstone of treatment for choroid plexus papilloma.
  • Effective management of choroid plexus carcinoma requires a multidisciplinary approach.
  • Further research is needed to improve therapeutic strategies and survival for pediatric choroid plexus carcinoma.

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