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Updated: Aug 25, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
Anatomy of headache and facial pain
1Department of Otolaryngology, Tufts University School of Medicine, New England Medical Center, 750 Washington Street, Box 850, Boston, MA 02111, USA. dlarrier@tufts-nemc.org
Abstract:
In this article we review the neural and vascular supply contributing to headache and facial pain. A detailed review of the neuroanatomy, particularly of the trigeminal contribution, was formulated. Emphasis was placed on outlining the dural, supratentorial, and facial structures innervated. A detailed review of the vascular anatomy is performed, with demonstration of the trigeminal innervation of key vascular structures. An outline of pain-sensitive cranial structures is also described. The pathways examined in this article serve as the basis on which concepts of headache and facial pain will build.
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