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Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats
H Süleyman1, L O Demirezer, A Kuruüzüm-Uz
1Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Abstract:
The effects of an aqueous root extract from Rumex patientia (D-1) compared to COX-2 selective inhibitors on indomethacine and ethanol induced stomach ulcers were investigated. Adult male Wistar albino rats, weighing between 185-200 g were used. It was determined that D-1 does not show its gastroprotective activity via a COX enzyme in indomethacine induced ulcers. Antioxidant effects protect the gastrointestinal system. The effect of D-1 in ethanol induced ulcers may also be due to its antioxidant effect.