Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute liver failure: prognostic markers.

Yogesh Batra1, S K Acharya

  • 1Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110 029.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|March 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indian National Association for the Study of Liver (INASL) Guidance Statements for Determining Futility in Liver Transplantation.

Journal of clinical and experimental hepatology·2025
Same author

Erratum to 'Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure' [J Clin Exp Hepatol 10 (2020) 477-517].

Journal of clinical and experimental hepatology·2022
Same author

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.

Journal of clinical and experimental hepatology·2020
Same author

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

Journal of clinical and experimental hepatology·2020
Same author

Avalanches and criticality in self-organized nanoscale networks.

Science advances·2019
Same author

Acetic acid versus radiofrequency ablation for the treatment of hepatocellular carcinoma: A randomized controlled trial.

Diagnostic and interventional imaging·2019

Acute liver failure (ALF) has a high mortality rate. Identifying patients needing liver transplantation is crucial, as current prognostic criteria show similar effectiveness in predicting outcomes.

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Critical Care Medicine

Background:

  • Acute liver failure (ALF) presents a grave prognosis with high mortality rates.
  • Current management strategies for ALF remain largely conservative, with limited success for novel therapies.
  • Liver transplantation offers improved survival but faces challenges of cost, lifelong immunosuppression, and organ scarcity.

Purpose of the Study:

  • To review and compare existing prognostic criteria for acute liver failure.
  • To emphasize the necessity of selecting high-risk patients for liver transplantation.
  • To evaluate the effectiveness of various clinical and laboratory parameters in predicting ALF outcomes.

Main Methods:

  • Review of established prognostic criteria for ALF, including Western and Eastern developed systems.

Related Experiment Videos

  • Comparison of the King's College criteria with criteria from other institutes (e.g., our institute, PGIMER Chandigarh).
  • Analysis of clinical and laboratory parameters such as prothrombin time, serum bilirubin, age, cerebral edema, and jaundice-encephalopathy interval.

    • Main Results:

    • Prognostic criteria primarily utilize clinical and laboratory parameters (coagulation, bilirubin) or liver volume.
    • Western criteria incorporate etiology and jaundice-encephalopathy interval, unlike some Eastern criteria.
    • Specific markers like prolonged prothrombin time, elevated bilirubin, older age, and cerebral edema are identified as poor prognostic indicators across different criteria.

    Conclusions:

    • Existing prognostic criteria for ALF demonstrate comparable sensitivity and specificity.
    • Accurate prognostication is vital for appropriate patient selection for liver transplantation.
    • Further refinement of prognostic models may improve patient management and resource allocation in ALF.