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Hepatic encephalopathy in pregnancy.

Rakesh Aggarwal1

  • 1Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014. rakesh@sgpgi.ac.in

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|March 18, 2004
PubMed
Summary

Hepatic encephalopathy in pregnancy has diverse causes, with Hepatitis E virus being significant in endemic areas. Treatment generally mirrors non-pregnant cases, though pregnancy termination may benefit some specific liver conditions.

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Area of Science:

  • Hepatology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Hepatic encephalopathy during pregnancy stems from various acute and chronic liver diseases.
  • Hepatitis E virus infection is a critical etiological factor in developing countries where it is endemic.

Purpose of the Study:

  • To review the causes, diagnosis, and treatment of hepatic encephalopathy in pregnancy.
  • To highlight the significance of Hepatitis E virus as a cause in endemic regions.

Main Methods:

  • Review of epidemiological, clinical, and laboratory findings for etiological diagnosis.
  • Comparison of treatment strategies for hepatic encephalopathy in pregnant versus non-pregnant patients.

Main Results:

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  • Diverse liver diseases can cause hepatic encephalopathy in pregnancy.
  • Hepatitis E virus is a prominent cause in endemic areas.
  • Standard treatments for hepatic encephalopathy are generally applicable.

    • Conclusions:

    • Etiological diagnosis relies on comprehensive patient data.
    • Termination of pregnancy may be beneficial for acute fatty liver of pregnancy and pre-eclampsia-related liver injury.
    • The utility of pregnancy termination in viral hepatitis-induced hepatic encephalopathy requires further study.