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Related Experiment Videos

Vimentin expression in breast carcinomas.

S R Niveditha1, Pramila Bajaj

  • 1Department of Pathology, Lady Hardinge Medical College, New Delhi. srniveditha@hotmail.com

Indian Journal of Pathology & Microbiology
|March 18, 2004
PubMed
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Vimentin expression in breast cancer indicates aggressive tumors. This study found vimentin positive tumors were larger, poorly differentiated, and receptor negative, suggesting a poorer prognosis.

Area of Science:

  • Oncology
  • Pathology
  • Biomarkers

Background:

  • Epithelial malignancies can express mesenchymal markers, influencing prognosis.
  • Vimentin is a mesenchymal marker implicated in tumor progression.

Purpose of the Study:

  • To investigate vimentin expression in breast carcinomas.
  • To correlate vimentin expression with clinical and histopathological parameters.

Main Methods:

  • Fifty cases of breast carcinoma were analyzed for vimentin expression.
  • Immunohistochemistry was used to detect vimentin.
  • Statistical analysis correlated vimentin status with tumor characteristics.

Main Results:

  • Eighteen percent (9/50) of breast carcinomas expressed vimentin.

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  • Vimentin-positive tumors were larger (mean 5.43 cm), higher TNM stage, poorly differentiated, and had high mitotic rates.
  • Vimentin-positive tumors were predominantly Estrogen and Progesterone receptor-negative.
  • Vimentin expression was observed even in some well and moderately differentiated tumors.
  • Metastasis and muscle infiltration were noted in some vimentin-positive cases.

    • Conclusions:

    • Vimentin expression is associated with aggressive biological behavior in breast cancer.
    • Vimentin may serve as a prognostic indicator for aggressive breast carcinomas.