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Updated: Aug 25, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
Published on: November 1, 2014
The high affinity receptor for IgE, FcepsilonRI
1NIAMS, NIH, Room 9N-228 10 Center Drive MSC 1820, Bethesda, MD 20892-1820, USA.
Abstract:
Progress in our understanding of the structure and function of the receptor with high affinity for IgE (FcepsilonRI) is already being applied in attempts to mitigate allergic reactions, specifically by using specific anti-IgEs to prevent sensitization. Investigations of the complex network of intracellular signals generated by FcepsilonRI and related receptors are proceeding. Although achieving a 'complete' description of the events will be a daunting task, the effort is likely to identify additional targets for therapeutic intervention along the way.
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