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Updated: Aug 25, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
[Recent progress in molecular mechanisms of chromosome instability and their association with carcinogenesis]
1Cancer Research Institute, Xiangya School of Medicine, Central Southern University, Changsha, Hunan, 410078, PR China.
Abstract:
The persistent presence of chromosome instability (CIN) has been demonstrated in majority of human cancers, particularly in solid cancers. Recent progress in molecular and cellular biology as well as cytogenetic has shed light on the possible molecular mechanisms and their association with carcinogenesis. Chromosome instability may result from various causes, including defects of mitotic spindle checkpoint, centrosome aberration, failure of cell cycle checkpoint, DNA double strand break, telomeres dysfunction, hypomethylation and so on. The researches broaden new insight in molecular mechanisms of carcinogenesis and provided new ideas in diagnoses, therapy, classification, and prognosis of cancer.
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