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Updated: Jan 31, 2026

Identification of Functional Protein Regions Through Chimeric Protein Construction
Published on: January 8, 2019
Hydrophobicity analysis of protein primary structures to identify helical regions
1Department of Biomedical Engineering, Polytechnic University of Milan, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. pattini@biomed.polimi.it
Objectives:
A wavelet based approach for the hydrophobicity analysis of protein primary structures is proposed to predict the presence of alpha helices in the secondary structure.
Methods:
The information about hydropathy profile periodicity content together with a score of probability of occurrence of a single amino acid allows the localization of alpha helices.
Results:
The accuracy is comparable to other consolidated predictors based on different techniques (i.e.: neural networks, hidden markov models).
Conclusion:
This method is particularly suitable to capture the amphiphilic character of the helical structures.
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