Related Experiment Video
Updated: Aug 25, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
[The neurotropic activity of food-derived opioid peptides beta-casomorphins]
V A Dubynin1, Iu A Ivleva, A A Kamenskiĭ
1Lomonosov State University, Faculty of Biology, Department of Human and Animal Physiology.
Abstract:
In the review the history of food-derived opioid peptides beta-casomorphins (beta-cas) discovery is given. The beta-cas formation in gastrointestinal tract during the beta-casein degradation and the following penetration into the blood are described, in the first place in newborn mammals. The attention is focused on neurotropic activity of beta-cas: their influence on the pain sensitivity, locomotion, anxiety and learning of experimental animals. The beta-cas ability to change the characteristics of mother-infant interaction is specially analysed. The necessity to take into consideration of beta-cas physiological effects on nursing dams and newborns behaviour is noted.
Related Concept Videos
Opioid Receptors: Overview
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Analgesia and Pain Management
Neurochemical Transmission: Sites of Drug Action
Drugs Affecting Neurotransmitter Synthesis

