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Related Experiment Videos

The ets gene family.

K Macleod1, D Leprince, D Stehelin

  • 1CNRS, Institut Pasteur, Lille, France.

Trends in Biochemical Sciences
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Ets proteins, crucial for gene regulation, bind DNA to control transcription. Some Ets family members interact with AP-1 or serum response factor (SRF), influencing cellular processes and disease.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Ets proteins are transcription factors with a conserved DNA-binding domain.
  • They regulate gene expression from various promoter and enhancer elements.
  • The Ets family plays roles in cellular and viral gene regulation.

Purpose of the Study:

  • To elucidate the diverse regulatory roles of Ets proteins.
  • To understand the interactions of specific Ets family members with other transcription factors.
  • To explore the involvement of Ets genes in cellular transformation and disease.

Main Methods:

  • Analysis of DNA-binding domains of Ets proteins.
  • Investigating transcriptional regulation by Ets proteins.
  • Studying interactions with AP-1 and serum response factor (SRF).

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Main Results:

  • Ets proteins regulate transcriptional initiation.
  • Ets-1 and Ets-2 cooperate with AP-1 (fos and jun).
  • Elk-1 and SAP-1 form complexes with SRF.
  • Some Ets members exhibit transforming activity.
  • Proviral integration activates Ets genes in erythroleukemias.

Conclusions:

  • Ets proteins are key regulators of gene transcription.
  • Specific Ets family members interact with distinct co-factors like AP-1 and SRF.
  • Ets gene dysregulation is implicated in oncogenesis and leukemia.