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Malaria still a threat to life--a postmortem study.

S R Rane1, V M Bapat, W Holla

  • 1Department of Pathology, B. J. Medical College, Pune. ranelab@vsnl.com

Indian Journal of Pathology & Microbiology
|March 19, 2004
PubMed
Summary

This autopsy study of 25 acute malaria cases revealed an increasing trend in malaria deaths. Plasmodium falciparum malaria, particularly cerebral malaria, was the leading cause of mortality, often presenting with fever, chills, and central nervous system symptoms.

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Area of Science:

  • Pathology
  • Infectious Diseases
  • Public Health

Background:

  • Malaria remains a significant cause of mortality worldwide.
  • Understanding autopsy findings in fatal malaria cases is crucial for public health interventions.
  • Plasmodium falciparum is the most virulent malaria parasite, associated with severe complications.

Purpose of the Study:

  • To analyze autopsy findings in fatal cases of acute malaria.
  • To identify the primary causes of death and common complications in malaria fatalities.
  • To observe trends in malaria-related deaths over a six-year period.

Main Methods:

  • Retrospective analysis of 25 autopsy cases of acute malaria.
  • Data collection included patient demographics, clinical presentations, and autopsy findings.

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  • Categorization of causes of death and associated complications.

    • Main Results:

    • Malaria was confirmed as the cause of death in all 25 cases.
    • An upward trend in malaria-related deaths was observed from 1994 to 1999.
    • Plasmodium falciparum malaria accounted for the majority of deaths, with cerebral malaria being the most frequent complication.

    Conclusions:

    • Acute Plasmodium falciparum malaria, especially cerebral malaria, is a major cause of death.
    • Severe malaria can lead to life-threatening complications such as ARDS, ARF, and DIC.
    • Fever, chills, and CNS symptoms are common indicators of severe malaria.