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Published on: June 23, 2019
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells
Fabio Carraro1, Annalisa Pucci, Antonella Naldini
1Dipartimento di Fisiologia, Unità di Fisiologia Cellulare e Molecolare, Università degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.
Abstract:
Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC, known to overexpress Src. The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast cancer cells.
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