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Related Experiment Videos

Estimating contaminant dose for intermittent dermal contact: model development, testing, and application.

W J Riley1, T E McKone, E A Cohen Hubal

  • 1Earth Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA.

Risk Analysis : an Official Publication of the Society for Risk Analysis
|March 19, 2004
PubMed
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A new model accurately predicts pesticide absorption through skin by simulating realistic contact scenarios. This simplifies exposure assessments, using cumulative contact time to reliably estimate dermal uptake in children.

Area of Science:

  • Environmental Health
  • Toxicology
  • Computational Modeling

Background:

  • Dermal exposure assessments in residential settings often rely on assumptions about skin contact.
  • Predicting cumulative pesticide doses requires understanding exposure scenarios, skin loading/unloading rates, and epidermal transport.

Purpose of the Study:

  • To develop and validate a finite-difference model for contaminant transport through the epidermis.
  • To create archetypal exposure scenarios and estimate loading/unloading rates based on behavioral data.
  • To quantify 24-hour dermal pesticide accumulation using Monte Carlo simulations.

Main Methods:

  • Developed the Transient Transport through the epiDERMis (TTDERM) numerical model for epidermal contaminant transport.
  • Created archetypal exposure scenarios using behavioral data to determine loading and unloading rates.

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  • Applied Monte Carlo simulations to quantify 24-hour uptake under variable conditions.

    • Main Results:

    • The TTDERM model accounts for variable exposure durations, skin properties, and parameter uncertainties.
    • A power law relationship was identified between cumulative contact time and mass transport through the skin for children.
    • Cumulative contact time offers a reliable simplification for predicting dermal uptake compared to micro-activity simulations.

    Conclusions:

    • The developed methods enhance dermal exposure models and inform the design of exposure measurement studies.
    • Simplified models using cumulative contact time can accurately predict pesticide uptake.
    • This research provides a more reliable approach to assessing aggregate dermal exposure in residential environments.