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Related Experiment Videos

Activity-responsive pacing produces long-term heart rate variability.

Satish R Raj1, Daniel E Roach, Mary-Lou Koshman

  • 1Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada.

Journal of Cardiovascular Electrophysiology
|March 19, 2004
PubMed
Summary

Long-term heart rate variability (HRV) measures, like SDANN and beta slope, may reflect physical activity. Rate-responsive pacing mimics these long-term HRV markers but not short-term ones.

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Area of Science:

  • Cardiology
  • Physiology
  • Biomedical Engineering

Background:

  • Long-term heart rate variability (HRV) measures, such as SDANN and beta slope, are significant prognostic indicators.
  • The physiological underpinnings of these long-term HRV metrics remain largely unknown.
  • This study investigates the relationship between physical activity and long-term HRV in patients with pacemakers.

Purpose of the Study:

  • To test the hypothesis that long-term HRV originates from physical activity.
  • To compare long-term and short-term HRV measures across different pacemaker pacing modes.

Main Methods:

  • A randomized cross-over study was conducted involving ten patients with complete heart block and dual-chamber pacemakers.
  • Patients underwent 24-hour ambulatory ECG monitoring in three pacing modes: atrially tracked, fixed-rate, and rate-responsive.

Related Experiment Videos

  • Key HRV metrics, including SDANN, ULF power, beta slope (long-term), and rMSSD, HF power (short-term), were calculated.

    • Main Results:

    • Long-term HRV measures (SDANN, ULF, beta slope) were significantly higher with atrially tracked and rate-responsive pacing compared to fixed-rate pacing (P < 0.0002).
    • Short-term HRV measures (rMSSD, HF power) were similar between fixed-rate and rate-responsive pacing and lower than with atrially tracked pacing (P = 0.0034).

    Conclusions:

    • Rate-responsive pacing effectively replicates long-term HRV measures.
    • However, rate-responsive pacing does not replicate short-term HRV measures.
    • These findings suggest that long-term HRV metrics may serve as indicators of a patient's physical activity levels.