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Related Experiment Videos

Confirming microarray data--is it really necessary?

John C Rockett1, Gary M Hellmann

  • 1Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA. rockett.john@epa.gov

Genomics
|March 19, 2004
PubMed
Summary

Mandatory corroboration of microarray data is burdensome and may be inappropriate. Clearer guidelines are needed for acceptable corroborative studies in life science research.

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Area of Science:

  • Life Sciences
  • Genomics
  • Bioinformatics

Background:

  • Microarray data verification often relies on corroborative data.
  • Journal policies increasingly require corroborative studies for microarray data.
  • Existing guidelines for microarray experiments do not adequately address corroboration.

Purpose of the Study:

  • To evaluate the necessity and appropriateness of mandatory corroborative studies for microarray data.
  • To identify challenges and ambiguities in current practices for corroborating microarray data.
  • To propose a collaborative approach for developing clear guidelines on corroborative studies.

Main Methods:

  • Analysis of arguments for and against corroborative microarray data studies.
  • Review of current and proposed journal policies on data corroboration.

Related Experiment Videos

  • Reporting results of a poll of 76 life science journals regarding their policies.

    • Main Results:

    • A fixed requirement for corroborating microarray data is considered overly burdensome and potentially inappropriate for some applications.
    • Lack of clear guidance exists on what constitutes an acceptable corroborative study.
    • A significant number of journals are considering or have implemented policies requiring corroborative data.

    Conclusions:

    • A blanket requirement for corroborating microarray data is not universally suitable and imposes undue burdens.
    • There is a need for inclusive efforts among stakeholders to establish clear, practical guidelines for acceptable corroborative studies.
    • Addressing the ambiguities surrounding corroborative data is crucial for the integrity and advancement of microarray research.