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Updated: Jul 29, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Osteosarcoma of the pelvis
D Donati1, S Giacomini, E Gozzi
1Department of Musculoskeletal Oncology and Orthopaedic Surgery, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy. davide.donati@ior.it
Summary
Outcomes for pelvic osteosarcoma patients are poor, with limited local control despite aggressive treatment. Tumor necrosis, however, indicates a better prognosis for these rare bone cancers.
Area of Science:
- Orthopedic Oncology
- Skeletal Tumors
- Sarcoma Research
Background:
- Pelvic osteosarcoma is a rare and aggressive bone malignancy.
- Treatment strategies and outcomes require further elucidation.
Purpose of the Study:
- To report outcomes for a significant cohort of pelvic osteosarcoma patients.
- To establish guidelines for optimal treatment of this condition.
Main Methods:
- Retrospective review of 60 consecutive patients with primary high-grade pelvic osteosarcoma.
- Analysis of tumor location, surgical interventions, and survival data.
Main Results:
- High rates of metastasis led to universal mortality in affected patients.
- Despite wide surgical margins in 18 cases, local recurrence occurred in eight.
- Overall survival was poor, with only eight patients alive at the end of the study.
Conclusions:
- Intensive chemotherapy and wide surgical margins show limited efficacy in achieving local control.
- Tumor necrosis is a significant positive prognostic indicator.
- Amputation should be considered when internal hemipelvectomy is insufficient, especially in cases involving sciatic nerve roots or in elderly patients.
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