Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Adjunct treatments in acute mania].

P Thomas1

  • 1Cinique de Psychiatrie, CHRU de Lille, Faculté de Médecine Henri Warembourg, Université Lille II, 6, rue du Professeur Laguesse, 59037 Lille cedex.

L'Encephale
|March 19, 2004
PubMed
Summary

Treating acute mania often involves polypharmacy. Antipsychotics and benzodiazepines are used adjunctively with mood stabilizers, but their specific indications and risks require careful consideration for optimal patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Right atrial thrombus migration during echocardiography: a case for urgent intervention.

European heart journal·1992
Same author

Cost-effectiveness of single dose cefotaxime plus metronidazole compared with three doses each of cefuroxime plus metronidazole for the prevention of wound infection after colorectal surgery.

The Journal of antimicrobial chemotherapy·1992
Same author

Stimulation of in vitro steroidogenesis by pituitary hormones in a turtle (Trachemys scripta) within the temperature-sensitive period for sex determination.

Biology of reproduction·1992
Same author

Extradural abscess complicating extradural anaesthesia for caesarean section.

British journal of anaesthesia·1992
Same author

Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker, Micropogonias undulatus.

General and comparative endocrinology·1992
Same author

Advances at the cutting edge.

The New Zealand nursing journal. Kai tiaki·1992

Area of Science:

  • Psychiatry and Pharmacology
  • Neuroscience
  • Clinical Therapeutics

Context:

  • Acute manic states present complex treatment challenges requiring rapid yet cautious therapeutic decisions.
  • Current guidelines suggest monotherapy with mood stabilizers for limited cases of mania.
  • Antipsychotics and benzodiazepines are frequently used adjunctively, often beyond recommended indications.

Purpose:

  • To delineate clinical scenarios necessitating adjunct treatments in acute mania.
  • To analyze the advantages and disadvantages of combining antipsychotics and/or benzodiazepines with mood stabilizers.
  • To establish differentiated indications for adjunctive therapies in mania management.

Summary:

  • Mania with agitation, sleep disturbances, or psychotic symptoms typically requires mood stabilizers combined with sedatives, hypnotics, or antipsychotics.
  • Conventional antipsychotics are widely used initially but have controversies regarding efficacy, delayed action, and significant adverse events, especially in bipolar patients.
  • Newer antipsychotics show acceptable safety profiles for acute psychotic mania, while benzodiazepines are indicated for mania with anxiety, catatonia, or insomnia, considering comorbidities.

Impact:

  • Provides evidence-based guidance for optimizing adjunctive treatment strategies in acute mania.
  • Highlights the need for judicious use of antipsychotics due to adverse event profiles and long-term effects.
  • Informs clinical practice regarding the selective use of benzodiazepines based on specific manic symptom clusters and comorbidities.

Related Experiment Videos