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Updated: Aug 25, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
[Microflora of the voice prostheses]
V O Ol'shanskiĭ1, E N Novozhilova, V V Dvornichenko
1Moskovskiĭ nauchno-issledovatel'skiĭ institut im. P. A. Gertsena, gorodskaia onkologicheskaia bol'nitsa #62, Moskva; Irkutskiĭ oblastnoĭ onkodispanser.
Abstract:
The study was made of the condition of voice prostheses Provox and Blom-Singer in 27 patients wearing them. The prostheses were to be replaced by new ones as they lost impermeability for water. The prostheses were used for 6 months to 2 years. At the prosthesis removal from the tracheoesophageal bypass it was found that the esophageal flange and protective valve were contaminated with fungi and pathogenic bacteria. The valve was deformed, had limited motility and did not close tightly the esophageal opening of the prosthesis as the result of which liquid leaked into the airways. Bacteriological examination identified C.albicans, C.krusei, C.glabralis in 11 patients. Nistatin, flucostat, fluconasol, amphotericin were used in antifungal therapy. Prophylactic use of these drugs against fungi prolonged use of the prostheses 2-fold.
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