Related Experiment Videos
[Antioxidants in complex therapy of atherosclerosis: pro et contra]
Abstract:
The review contains current insights into the role of free radical processes in formation of oxidative stress in atherosclerosis and its relevance to therapy and prevention. Data of epidemiological studies evidence for existence of correlations between blood plasma content of antioxidant vitamins and presence of signs of atherosclerosis. However mostly positive data on the use of antioxidants in various animal experimental models of atherosclerosis contrast with equivocal results of therapeutic application of antioxidant vitamins in humans. Possible causes for this controversy have been choice of suboptimal combinations of components, extremely high concentrations of consumed substances, lack of biochemical testing of baseline antioxidant status and its changes in the process of therapy. The authors of the review suggest novel approaches to planning of clinical trials of antioxidant vitamins.
Related Concept Videos
Atherosclerosis III: Management
Atherosclerosis I: Introduction
Coronary Artery Disease I: Introduction
Atherosclerosis IV: Nursing Management
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...