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Updated: Aug 25, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
Upper gastrointestinal hemorrhage due to duodenal stromal tumor
José Gustavo Parreira1, Wilson de Freitas, Samir Rasslan
1Emergency Service, Department of Surgery, 'Santa Casa' School of Medicine, São Paulo, SP, Brazil. jgparreira@uol.comb.br
Background:
Gastrointestinal stromal tumor represents a rare neoplasm that originates in the muscular wall of the hollow viscera.
Aim:
To report gastrointestinal stromal tumor as a source of upper gastrointestinal bleeding, which required urgent surgical control.
Patient/Method:
A man with 61 years old was admitted to the emergency service sustaining hematemesis and melena. Endoscopy showed active bleeding from a tumor in the second portion of the duodenum, which was controlled by heater probe cauterization. Surgery was performed through a median laparotomy. A local resection of a 4 cm tumor in the second portion of the duodenum was carried out, together with a primary end-to-end anastomosis and a duodenal diverticulization. No complications happened during the post-operative period. Morphologic examination showed gastrointestinal stromal tumor with no atypical mitosis and a preserved capsule.
Conclusion:
Albeit not being common, gastrointestinal stromal tumors can represent a source of substantial gastrointestinal hemorrhage.
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