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Cerebral diffusion tensor images in children with tuberous sclerosis: a preliminary report
Steven Shinn-Forng Peng1, Wang-Tso Lee, Yao Hung Wang
1Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei 100 Taiwan. e510011@ha.mc.ntu.edu.tw
Pediatric Radiology
|March 19, 2004
Summary
Diffusion tensor imaging (DTI) reveals significant white matter changes in tuberous sclerosis (TS). These diffusion tensor imaging indices, including eigenvalues (EVs), apparent diffusion coefficients (ADCs), and fractional anisotropy (FA), can help demonstrate cerebral changes in TS patients.
Area of Science:
- Neuroimaging
- White Matter Diseases
- Diffusion Tensor Imaging
Background:
- Tuberous sclerosis (TS) is characterized by tubers typically affecting white matter.
- Diffusion tensor (DT) imaging is a key technique for visualizing white-matter tracts.
Purpose of the Study:
- To investigate alterations in DT indices within supratentorial tubers.
- To assess associated changes in adjacent white-matter tracts in TS patients.
Main Methods:
- DT imaging indices (eigenvalues, ADCs, FA) were measured in white matter lesions of tubers.
- Seven TS patients with developmental delay were compared to control subjects.
Main Results:
- Significant differences in EVs, ADCs, and FA were observed in white matter lesions compared to controls and contralateral regions.
- A negative correlation was found between tuber count and EV1 in the superior longitudinal fasciculi.
- TS patients showed increased ADCs in the corona radiata and sagittal stratum, and increased EV3s in the inferior longitudinal fasciculus and sagittal stratum.
Conclusions:
- DT imaging indices (EVs, ADCs, FA) are valuable for detecting cerebral white matter abnormalities in TS.
- These quantitative measures can aid in the diagnosis and understanding of TS-related white matter pathology.