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Updated: Aug 25, 2026

Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
Published on: February 16, 2024
[Importance of the vaginal ecosystem examination in the first trimester of pregnancy]
1Centrum Zwalczania Zakazeń w Połoznictwie, Ginekologii i Urologii Instytutu Matki i Dziecka w Warszawie.
Objectives:
Vaginal ecosystem disturbances especially bacterial vaginosis are strongly associated with infectious complication during the course of pregnancy.
Design:
The aim of the study was the determination of the vaginal ecosystem examination for the diagnosis of the following infection: bacterial vaginosis, candidiasis and trichomoniasis in pregnant women in the first trimester of pregnancy.
Materials And Methods:
The studies included 106 randomly selected asymptomatic pregnant women in I trimester of pregnancy coming for gynaecological examination for the first time after cessation of menstruation were divided into two group: 56 primiparae and 50 multiparae. The diagnosis of BV was based on Amsel criteria concerning vaginal secretion. Trichomonas vaginalis was determined in wet vaginal smear. Candida albicans was detected in vaginal smear after addition of 10% KOH solution.
Results:
Out of 106 studied subjects in the first trimester of pregnancy, BV was detected in 17.9%, Candida albicans in 15.1%, Trichomonas vaginalis in 3.8%. The detectability of BV infection varied significantly between both groups of studied women (p < 0.001) while no correlation was found between the occurrence of Candida albicans and Trichomonas vaginalis infections.
Conclusion:
Vaginal ecosystem screening in pregnant women makes possible under ambulatory conditions, to detect the following infections: BV, candidiasis and trichomoniasis. Determination of disturbances in vaginal ecosystem is simple and inexpensive, not requiring laboratory facilities for the assessment of vaginal infections.
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