Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electron tunneling through proteins.

Harry B Gray1, Jay R Winkler

  • 1Beckman Institute, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125-7400, USA. hbgray@caltech.edu

Quarterly Reviews of Biophysics
|March 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multistep electron tunneling through tryptophans in the KatG bifunctional peroxidase monitored by a nonperturbing spin probe.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer model.

bioRxiv : the preprint server for biology·2026
Same author

Electron Transport through a Tryptophan Quadruplex in a Dimeric Azurin Construct.

The journal of physical chemistry. B·2026
Same author

Oxidizable amino acids around cytochrome P450 hemes.

Journal of inorganic biochemistry·2025
Same author

Real-Time Tracking of Photoinduced Metal-Metal Bond Formation in a d<sup>8</sup>d<sup>8</sup> Di-Iridium Complex by Vibrational Coherence and Femtosecond Stimulated Raman Spectroscopy.

Journal of the American Chemical Society·2025
Same author

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth.

Nature nanotechnology·2025
Same journal

Lasing emission spectroscopy for bioanalytics and biomedicine.

Quarterly reviews of biophysics·2026
Same journal

Elementary processes and mechanisms of nanopore formation induced by antimicrobial peptides and other membrane-active peptides.

Quarterly reviews of biophysics·2026
Same journal

Biomineralization: Perspectives on control of crystal polymorphism, order-disorder and solvation states.

Quarterly reviews of biophysics·2026
Same journal

The pivotal roles of cellular biophysics and mechanobiology in the development of Human Organs-on-Chips.

Quarterly reviews of biophysics·2026
Same journal

Biophysics meets fungal biology: Characterising the fungal cell envelope and its interactions with drug-like molecules.

Quarterly reviews of biophysics·2026
Same journal

Energy landscapes in molecular biology: History, principles, and perspectives.

Quarterly reviews of biophysics·2026
See all related articles

Biological electron transfer, essential for cellular energy, is governed by protein structure. Research on Ru-modified proteins reveals electron tunneling rates across distances, aiding in understanding optimized biological energy transduction.

Area of Science:

  • Biochemistry and Biophysics
  • Bioenergetics and Energy Transduction
  • Molecular Biology

Background:

  • Electron transfer processes are fundamental to energy transduction in living cells.
  • Over 50 years of research has detailed the regulation of biological electron transfer.
  • Understanding these 'currents of life' is crucial for comprehending cellular energy dynamics.

Purpose of the Study:

  • To review investigations of Ru-modified proteins to understand intra-protein electron transfer rates.
  • To discuss electron transfer across protein-protein interfaces.
  • To present an experimentally validated timetable for electron tunneling distances in proteins.

Main Methods:

  • Investigations of Ruthenium (Ru)-modified proteins to delineate distance and driving-force dependences.

Related Experiment Videos

  • Probing electron transfer across protein-protein interfaces in solution and crystal states.
  • Comparison of experimental electron tunneling rates with theoretical predictions.

    • Main Results:

    • Established clear distance and driving-force dependences for intra-protein electron transfer rates.
    • Demonstrated that protein structures tune thermodynamic properties and electronic coupling for electron tunneling.
    • Observed agreement between predicted and experimental electron tunneling rates in cytochrome c oxidase and photosynthetic reaction centers.
    • Identified some reactions exceeding predictions, likely due to multistep tunneling.

    Conclusions:

    • Protein structures play a critical role in facilitating electron tunneling for biological energy transduction.
    • The developed timetable accurately predicts many biological electron transfer rates, indicating optimized natural processes.
    • Anomalously fast electron transfer rates suggest the involvement of multistep tunneling mechanisms.