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Polymorphic 33-bp repeats with promoter-like activity in synaptotagmin 11 gene
Hiroshi Yokota1, Takahiro Tsujita, Yuji Okazaki
1Proteome Research Laboratory, Daiichi Pharmaceutical Co., 519 Shimo-Ishibashi, Ishibashi, Shimotsuga-gun, Tochigi 329-0512, Japan.
Abstract:
In the immediate upstream region of the transcription initiation site of human synaptotagmin 11 gene, we found a tandem repeat of a 33-bp unit with a promoter-like activity. The tandem repeat is apparently polymorphic in the Japanese population as two DNA samples from 60 schizophrenia patients exhibited an increased number (three) of the unit. In a transfection assay using constructs with different numbers of repeats, the promoter-like activity was found to increase with the number of repeating unit.