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[Aspergillus flavus endocarditis on a native valve].

D Irles1, A Bonadona, J Pofelski

  • 1Unité de réanimation médicale, département de médecine aiguë spécialisée, CHU de Grenoble.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|March 23, 2004
PubMed
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A rare case of Aspergillus flavus endocarditis complicated a patient with acute T lymphoid leukemia undergoing chemotherapy. Despite treatment, invasive aspergillosis led to rapid multiorgan failure and death.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Hematology

Background:

  • Acute T lymphoid leukemia (T-ALL) treatment often involves chemotherapy, leading to immunosuppression.
  • Febrile aplasia is a common complication during chemotherapy for leukemia.

Observation:

  • A 33-year-old female with T-ALL developed Stenotrophomonas maltophilia septic shock and pneumonia post-chemotherapy.
  • She later presented with necrotic skin lesions, and biopsy revealed Aspergillus flavus.
  • Echocardiography confirmed Aspergillus endocarditis on the mitral valve.

Findings:

  • The patient experienced rapid clinical deterioration despite antibiotic and antifungal therapy.
  • Cerebral CT scan indicated multiple septic emboli.
  • The case progressed to multiorgan failure and death.

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Implications:

  • Aspergillus endocarditis is an exceptionally rare but devastating complication in immunocompromised patients.
  • Early diagnosis and treatment are challenging, with extremely high mortality rates.
  • This case highlights the critical need for vigilance in diagnosing invasive fungal infections in leukemia patients.