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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
[Respiratory infection due to Chlamydia trachomatis in infants. Clinical presentation and outcome in 18 patients]
M A Marín Gabriel1, S de las Heras Ibarra, E Bergón Sendín
1Seccion de Inmunodeficiencia, Hospital 12 de Octubre, Madrid, Spain.
Insights
Chlamydia trachomatis can cause serious lower respiratory tract disease in infants under six months. Early diagnosis and treatment are crucial, as infection may require hospitalization and intensive care.
Area of Science:
- Pediatrics
- Infectious Diseases
- Bacteriology
Context:
- Chlamydia trachomatis is a common bacterial pathogen.
- It causes various infections in men, women, and children.
- In infants, it can lead to conjunctivitis and lower respiratory tract disease.
Purpose:
- To highlight the potential severity of Chlamydia trachomatis lower respiratory tract disease in infants.
- To emphasize the need for increased awareness and prompt diagnosis.
Summary:
- A retrospective review identified 18 infants under 6 months with C. trachomatis lower respiratory tract disease.
- 17 infants required hospitalization, and 5 needed pediatric intensive care.
- Symptoms included apnea and interstitial infiltrates on chest X-ray; all infants recovered with erythromycin treatment.
Impact:
- C. trachomatis infection should be considered in infants presenting with lower respiratory tract symptoms, especially when other pathogens are absent.
- This underscores the importance of ruling out C. trachomatis in hospitalized infants with respiratory distress.
- Prompt identification and treatment can prevent severe outcomes and reduce hospital stays.
Background:
Among other diseases, Chlamydia trachomatis causes epididymitis and prostatitis in men and urethritis, cervicitis and pelvic inflammatory disease in women. In children, it most usually causes conjunctivitis and is also responsible for lower respiratory tract disease, occasionally requiring hospital admission.
Objective:
To draw attention to this disease, which is usually overlooked and which can be potentially serious.
Methods:
We retrospectively reviewed the medical records of infants aged less than 6 months with symptoms of lower respiratory tract disease in whom C. trachomatis antigen was detected by enzyme immunoassay.
Results:
We identified 18 patients with C. trachomatis between 1993 and 2002. Of these, 17 patients required hospital admission and five required monitoring in the pediatric intensive care unit. The mean length of hospital stay was 9.6 days. Three patients were immigrants. The mean age at admission was 6.6 weeks. Apnea occurred in five infants. Chest x-ray showed interstitial infiltrates in five infants. Sixteen patients were treated with erythromycin and all made a complete recovery.
Conclusions:
Although lower respiratory tract disease caused by C. trachomatis is usually managed on an outpatient basis, it sometimes requires hospital admission or even management in the intensive care unit. Therefore, C. trachomatis infection should be ruled out in infants aged less than 6 months with clinical symptoms of lower respiratory tract disease for which no other pathogen can be found.
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