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Relationship between stress and circulating levels of S100B protein
Sergio Scaccianoce1, Paola Del Bianco, Gaetano Pannitteri
1Department of Human Physiology and Pharmacology Vittorio Erspamer, University of Rome La Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy. sergio.scaccianoce@uniroma1.it
Abstract:
It has been proposed that S100B can be a marker for several pathological conditions including brain traumas, blood-brain barrier disruption, and ischemia. Because the hypothalamo-pituitary-adrenal axis is activated in these conditions, we investigated the role of glucocorticoids in the effects of stress on serum S100B. Restraint stress increased S100B levels in control and in adrenalectomized but not in corticosterone-injected rats. Adrenalectomy did not alter basal S100B. These results indicate a glucocorticoid-independent relationship between stress and S100B.