Related Experiment Video

Updated: May 7, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

The influence of hyperglycemia on outcome of cerebral infarction

D B Matchar1, G W Divine, A Heyman

  • 1Duke University, Durham, NC.

Annals of Internal Medicine
|September 15, 1992
PubMed

Insights

Hyperglycemia during acute stroke does not appear to impact survival or functional recovery. This study found no significant association between blood glucose levels and stroke outcomes.

Area of Science:

  • Neurology
  • Endocrinology
  • Clinical Research

Background:

  • Hyperglycemia is common in acute stroke patients.
  • The relationship between acute hyperglycemia and stroke outcomes remains debated.
  • Previous studies have not fully accounted for stress response and chronic hyperglycemia.

Purpose of the Study:

  • To investigate the association between acute hyperglycemia and stroke outcomes.
  • To determine if blood glucose levels predict survival and functional recovery post-stroke.
  • To differentiate the impact of acute vs. chronic hyperglycemia on stroke prognosis.

Main Methods:

  • Prospective, multicenter cohort study of 146 patients with atherothrombotic stroke.
  • Measured admission blood glucose, urinary catecholamines, serum cortisol, and glycosylated hemoglobin.
  • Assessed mortality and functional outcomes (Barthel index, Fugl-Meyer score) at multiple time points.

Main Results:

  • No significant univariate association was found between admission blood glucose and survival.
  • Admission blood glucose did not significantly correlate with functional outcomes at 30 days.
  • These findings persisted after adjusting for other predictors in a multivariate model.

Conclusions:

  • The study provides no evidence supporting a link between glycemia levels and acute stroke outcomes.
  • Acute hyperglycemia may not be a significant prognostic factor for stroke survival or function.
  • Further research may be needed to explore other factors influencing stroke prognosis.
Abstract

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Stroke05:32

Transient Middle Cerebral Artery Occlusion Model of Stroke

Published on: August 11, 2023

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Related Concept Videos

Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...