Related Experiment Video
Updated: May 2, 2026

Pseudomonas aeruginosa Induced Lung Injury Model
Published on: October 29, 2014
Minocycline-induced cell-mediated hypersensitivity pneumonitis
J M Guillon1, P Joly, B Autran
1Hôpital Tenon, Paris, France.
Objective:
To identify the cause of a hypersensitivity pneumonitis and to determine its pathogenesis.
Design:
Case study.
Setting:
Intensive care unit of a referral hospital.
Patient:
A 51-year-old man with chronic bronchitis who developed a hypersensitivity pneumonitis within 1 month after exposure to minocycline, amoxicillin, and erythromycin.
Intervention:
Sequential bronchoalveolar lavages after reexposure to minocycline and amoxicillin.
Measurements:
Immunologic analysis of the phenotype and function of alveolar lymphocytes.
Results:
Reexposure to minocycline but not to amoxicillin was followed by an interstitial pneumonitis. Sequential bronchoalveolar lavages showed a transient rise of eosinophils and neutrophils and a persistent alveolar lymphocytosis. Alveolar lymphocytes consisted predominantly of CD8+ but also CD4+ cells. Two CD8+ lymphocyte subsets were identified: CD8+ D44+ cytotoxic T cells that increased rapidly after the drug was resumed and CD8+ CD57+ suppressor T cells that predominated 11 days after the drug's withdrawal. In-vitro assays showed the presence of a lymphocyte-mediated specific cytotoxicity against minocycline-bearing alveolar macrophages.
Conclusion:
These results support the hypothesis of a central role of T lymphocytes in the pathogenesis of drug-related hypersensitivity pneumonitis.
Related Concept Videos
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Drug Toxicity: Allergic Reactions
Hypersensitivity Reactions: Cytolytic Reactions
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Atypical Pneumonia
Hypersensitivity Reactions: Immune-Complex Reactions

