Related Experiment Videos
Apoptosis gene network: description in the GeneNet and TRRD databases
Irina Stepanenko1, Nikolay Kolchanov
1Institute of Cytology and Genetics, SB RAS, Lavrentieva 10, 630090, Novosibirsk, Russia. stepan@bionet.nsc.ru
Annals of the New York Academy of Sciences
|March 23, 2004
Summary
Computer analysis of apoptosis data is essential for understanding gene networks. Databases like GeneNet and TRRD help systematize this information for various cell types and conditions.
Area of Science:
- Molecular Biology
- Bioinformatics
- Systems Biology
Background:
- Vast experimental data on apoptosis necessitates computational approaches for integration and analysis.
- Understanding the gene regulatory networks controlling apoptosis is crucial across different cell types and conditions.
Purpose of the Study:
- To describe the gene network regulating apoptosis using computational methods.
- To integrate experimental data on apoptosis gene regulation.
Main Methods:
- Utilizing the GeneNet database for apoptosis gene network descriptions.
- Leveraging the Transcription Regulatory Regions Database (TRRD) for experimental transcription regulation data.
Main Results:
- The GeneNet database provides a systematic description of the apoptosis gene network.
- The TRRD database compiles experimental data on the transcriptional regulation of apoptosis-related genes.
Conclusions:
- Computational databases are vital for organizing and interpreting complex biological data.
- Integrated databases facilitate a comprehensive understanding of gene regulatory networks, such as those governing apoptosis.