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Updated: Aug 25, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it
Kiyotaka Machida1, Hiroyuki Osada
1Antibiotics Laboratory, Riken, Hirosawa 2-1, Saitama 351-0198, Japan.
Abstract:
We propose a model for the mechanism of permeability transition (PT) related cytochrome c release. It is likely that the Ca(2+) requirement for the induction of the mitochondrial permeability transition pore (MPTP) opening might be due to the Ca(2+)-dependent interaction between cyclophilin D and ANT. We show here that the modification of adenine nucleotide translocase (ANT), which is one of the components of MPTP, can induce two different types of the cytochrome c release. One is dependent on classical PT, resulting in mitochondrial swelling, and is inhibited by cyclosporin A. The other is PT-independent, without swelling, and is insensitive to cyclosporin A.
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