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Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells
A M Porcelli1, A Ghelli, C Zanna
1Dipartimento di Biologia Ev. Sp., Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, 40126 Bologna, Italy. porcelli@alma.unibo.it
Annals of the New York Academy of Sciences
|March 23, 2004
Abstract:
Incubation of ECV304 cells with 1 micro M staurosporine (STS) causes apoptotic cell death. In the present study, we investigate whether a significant apoptotic volume decrease (AVD) was apparent during the very early times (1 h) of the apoptotic process. Our data suggest that upregulation of Cl(-) (and possibly K(+)) channels by STS may be a very early primary event required for the subsequent onset of AVD, which results in apoptosis.