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Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat
A Duvoix1, F Morceau, M Schnekenburger
1Laboratoire RCMS, Centre Universitaire du Luxembourg, 162A Avenue de la Faïencerie, L-1511 Luxembourg, Luxembourg.
Annals of the New York Academy of Sciences
|March 23, 2004
Abstract:
Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared in two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH(3) interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.