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Published on: April 15, 2015
Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a
P Fattoretti1, C Bertoni-Freddari, T Casoli
1Neurobiology of Aging Laboratory, N. Masera INRCA Research Department, 60121 Ancona, Italy. p.fattoretti@inrca.it
Abstract:
We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs. age-matched controls, and in adult- vs. old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death.
