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Updated: Jul 20, 2026

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Published on: November 10, 2009

Phosphorylation reactions in activity-dependent synapse modification at the neuromuscular junction during development

Phillip G Nelson1, Maria A Lanuza, Min Jia

  • 1Section on Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development/NIH, Bethesda, MD 20892-4480, USA. pgnelson@codon.nih.gov

Journal of Neurocytology
|March 23, 2004
PubMed

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Phosphorylation

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During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
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The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
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