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In vitro antistaphylococcal activity and testing of RP 59500, a new streptogramin, by two methods

K E Aldridge¹, D D Schiro, L M Varner

¹Louisiana State University Medical Center, New Orleans 70112.

Antimicrobial Agents and Chemotherapy

|April 1, 1992

Abstract:

The in vitro antistaphylococcal activity of RP 59500, a new streptogramin, was comparable to those of vancomycin and teicoplanin against Staphylococcus aureus, and RP 59500 was the most active agent against coagulase-negative staphylococci. All staphylococcal strains were inhibited by 4 micrograms of RP 59500 per ml, including multiply resistant strains. Broth microdilution and agar dilution testing gave comparable results in 97% of the tests with RP 59500.

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