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Related Experiment Videos

Delayed type hypersensitivity is abnormal in patients with lichen planus.

J L Rees1, J N Matthews, P S Friedmann

  • 1University Department of Dermatology, University of Newcastle upon Tyne, UK.

Archives of Dermatological Research
|January 1, 1992
PubMed
Summary

Patients with lichen planus show a weakened immune response in their skin. This suggests a potential primary defect in the cutaneous immune system, even in unaffected skin areas.

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Area of Science:

  • Immunology
  • Dermatology

Background:

  • Lichen planus involves a cell-mediated immune attack on the epidermis.
  • Investigating cutaneous immunity in non-lesional skin is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To assess the cutaneous immune response in patients with lichen planus compared to controls.
  • To determine if unaffected skin in lichen planus patients exhibits immune abnormalities.

Main Methods:

  • Contact sensitization was induced using dinitrochlorobenzene (DNCB) in 17 lichen planus patients and 27 controls.
  • Subjects were challenged with DNCB after 4 weeks, and responses were measured by skinfold thickness changes.
  • Skinfold thickness was quantified using calipers 48 hours post-challenge.

Main Results:

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  • Lichen planus patients demonstrated significantly reduced responsiveness to DNCB compared to controls.
  • Smaller allergic reactions were observed in patients across all challenge doses.
  • These findings indicate diminished cutaneous immune function in lichen planus.

Conclusions:

  • The study suggests a potential primary defect in the cutaneous immune system of lichen planus patients.
  • Abnormalities in immune response were noted even in skin areas not affected by the rash.
  • This highlights a possible systemic issue with skin immunity in lichen planus.