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Spectrophotometric determination of diltiazem in dosage forms
D Zivanov-Stakić1, D Agbaba, S Vladimirov
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
Farmaco (Societa Chimica Italiana : 1989)
|March 1, 1992
Abstract:
A simple and reproducible method for determination of diltiazem in bulk and in dosage forms is presented. The method is based on formation of hydroxamic acid, which reacts with iron (III), forming a complex with a maximum absorption at 525 nm. Assay procedure for diltiazem dosage form requires thin-layer chromatographic separation prior to colorimetric analysis.