Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Salmonella redirects phagosomal maturation.

John H Brumell¹, Sergio Grinstein

¹Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada. john.brunell@sickkids.ca

Current Opinion in Microbiology

|March 24, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Beyond transport: Lysosomal solute carriers as orchestrators of immune signaling.

Molecular biology of the cell·2026

Same author

Plasma membrane invaginations and their diverse cellular functions.

BMC biology·2026

Same author

A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread.

Nature communications·2026

Same author

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.

Molecular biology of the cell·2026

Same author

Correction: Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission.

PLoS pathogens·2025

Same author

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?

The Journal of cell biology·2025

Same journal

S-layers as natural building blocks for nanobiotechnology and synthetic biology.

Current opinion in microbiology·2026

Same journal

The role of the antimicrobial peptide nisin as a clean label food preservative.

Current opinion in microbiology·2026

Same journal

From coarse-grained metabolic rules to fine-grained control of microbial communities.

Current opinion in microbiology·2026

Same journal

Progress in engineered bacterial cancer therapies.

Current opinion in microbiology·2026

Same journal

Constraints on adaptive loss-of-function mutations during microbial metabolic interactions.

Current opinion in microbiology·2026

Same journal

Discovery of novel antimicrobials within microbiomes.

Current opinion in microbiology·2026

See all related articles

Salmonella bacteria survive inside host cells by hijacking a cellular compartment, preventing its transformation into a microbe-killing organelle. This allows the bacteria to create a safe haven for replication.

Area of Science:

Microbiology
Cell Biology
Infectious Diseases

Background:

Salmonella invades host cells, residing within a vacuole.
This vacuole normally matures into a microbicidal phagolysosome.
Salmonella actively interferes with this maturation process.

Purpose of the Study:

To understand how Salmonella evades host defenses within vacuoles.
To elucidate the mechanisms by which Salmonella manipulates vacuole maturation.

Main Methods:

Analysis of Salmonella-containing vacuole dynamics.
Investigation of host-pathogen interactions at the vacuolar membrane.
Microscopy and biochemical assays to track vacuole maturation markers.

Main Results:

Related Experiment Videos

Salmonella arrests the maturation of its containing vacuole.
The bacteria divert the vacuole away from the normal phagolysosomal pathway.
This leads to the creation of a protected intracellular niche.

Conclusions:

Salmonella actively remodels its vacuolar environment for survival.
Interference with vacuole maturation is crucial for Salmonella replication within host cells.
This strategy highlights a key virulence mechanism of Salmonella.