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Related Experiment Videos

Restless legs symptoms in thyroid disorders.

E K Tan1, S C Ho, P Eng

  • 1Department of Neurology, Division of Medicine, Singapore General Hospital, Outram Road, Singapore, Singapore 169608. gnrtek@sgh.com.sg

Parkinsonism & Related Disorders
|March 24, 2004
PubMed
Summary

Thyroid disorders are not linked to restless legs syndrome (RLS) prevalence. However, some patients with thyroid issues experienced RLS-like symptoms, which often resolved after thyroid treatment.

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Area of Science:

  • Neurology
  • Endocrinology

Background:

  • Dopaminergic dysfunction is implicated in both thyroid disorders and restless legs syndrome (RLS).
  • The relationship between thyroid dysfunction and RLS requires further investigation.

Purpose of the Study:

  • To evaluate the prevalence of RLS in patients with hyperthyroidism or hypothyroidism.
  • To compare RLS prevalence in thyroid disorder patients versus controls.

Main Methods:

  • Face-to-face interviews were conducted using International Restless Legs Syndrome Study Group (IRLSSG) criteria.
  • Patients with biochemically confirmed thyroid disorders (n=146) and controls (n=434) were assessed.

Main Results:

  • No significant difference in RLS prevalence was found between thyroid patients and controls (0% vs 0.2%).

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  • RLS-like symptoms (satisfying first 3 IRLSSG criteria) were more common in thyroid patients (8.2%) than controls (0.9%, p < 0.0001).
  • 33.3% of patients with RLS-like symptoms reported complete symptom resolution after thyroid treatment.

    • Conclusions:

    • Thyroid disorders are not associated with a higher prevalence of RLS.
    • RLS-like symptoms can occur in thyroid patients and may improve with thyroid treatment.