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Updated: Aug 25, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Pharmacological induction of tolerogenic dendritic cells and regulatory T cells

Luciano Adorini1, Nadia Giarratana, Giuseppe Penna

  • 1BioXell, Via Olgettina 58, Milano I-20132, Italy. Luciano.Adorini@bioxell.com

Seminars in Immunology
|March 24, 2004
PubMed

Immunosuppressive and anti-inflammatory agents are able to generate tolerogenic DCs, leading, in some cases, to induction or enhancement of regulatory T cells with suppressive activity. This novel mechanism of action, shared by several immunosuppressive and anti-inflammatory agents, is becoming firmly established and contributes to explain their functional properties. The possibility to manipulate DCs in vivo using more or less conventional low molecular weight drugs, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.

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